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Integration of epidemiology, immunobiology, and translational research for brain tumors

Identifieur interne : 005F38 ( Main/Exploration ); précédent : 005F37; suivant : 005F39

Integration of epidemiology, immunobiology, and translational research for brain tumors

Auteurs : Hideho Okada [États-Unis] ; Michael E. Scheurer [États-Unis] ; Saumendra N. Sarkar [États-Unis] ; Melissa L. Bondy [États-Unis]

Source :

Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2013-05.

RBID : ISTEX:6ADF7CC53AFC2E5D53010794B97DF6C53A32AE48

Descripteurs français

Wicri :
- topic : Allergie, Vaccin.

English descriptors

Abstract

We recently identified a pivotal role for the host type I interferon (IFN) pathway in immunosurveillance against de novo mouse glioma development, especially through the regulation of immature myeloid cells (IMCs) in the glioma microenvironment. The present paper summarizes our published work in a number of areas. We have identified single‐nucleotide polymorphisms (SNPs) in human IFN genes that dictate altered prognosis of patients with glioma. One of these SNPs (rs12553612) is located in the promoter of IFNA8 and influences its activity. Conversely, recent epidemiologic data show that chronic use of nonsteroidal anti‐inflammatory drugs lowers the risk of glioma. We translated these findings back to our de novo glioma model and found that cyclooxygenase‐2 inhibition enhances antiglioma immunosurveillance by reducing glioma‐associated IMCs. Taken together, these findings suggest that alterations in myeloid cell function condition the brain for glioma development. Finally, in preliminary work, we have begun applying novel immunotherapeutic approaches to patients with low‐grade glioma with the aim of preventing malignant transformation. Future research will hopefully better integrate epidemiological, immunobiological, and translational techniques to develop novel, preventive approaches for malignant gliomas.

Url:

https://api.istex.fr/document/6ADF7CC53AFC2E5D53010794B97DF6C53A32AE48/fulltext/pdf

DOI: 10.1111/nyas.12115

Affiliations:

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Le document en format XML

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<author><name sortKey="Scheurer, Michael E" sort="Scheurer, Michael E" uniqKey="Scheurer M" first="Michael E." last="Scheurer">Michael E. Scheurer</name>
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<author><name sortKey="Sarkar, Saumendra N" sort="Sarkar, Saumendra N" uniqKey="Sarkar S" first="Saumendra N." last="Sarkar">Saumendra N. Sarkar</name>
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<term>Adult glioma</term>
<term>Allergy</term>
<term>Antiglioma immunosurveillance</term>
<term>Biological mechanisms</term>
<term>Biomarkers prev</term>
<term>Bone marrow</term>
<term>Brain tumors</term>
<term>Cancer epidemiol</term>
<term>Cancer immunol</term>
<term>Celecoxib</term>
<term>Cell response</term>
<term>Cerebral glioma</term>
<term>Clin</term>
<term>Dendritic cells</term>
<term>Epidemiologic studies</term>
<term>European organization</term>
<term>Glioblastoma</term>
<term>Glioblastoma multiforme</term>
<term>Glioblastoma risk</term>
<term>Glioma</term>
<term>Glioma development</term>
<term>Glioma model</term>
<term>Glioma patients</term>
<term>Glioma vaccines</term>
<term>Hideho okada</term>
<term>High risk</term>
<term>Ifna8</term>
<term>Ifna8 promoter</term>
<term>Imcs</term>
<term>Immature myeloid cells</term>
<term>Immunologic factors</term>
<term>Immunological responses</term>
<term>International study</term>
<term>Intracranial gliomas</term>
<term>Lggs</term>
<term>Malignant glioma</term>
<term>Median survival</term>
<term>Myeloid</term>
<term>Myeloid cells</term>
<term>Ndings</term>
<term>Neuro oncol</term>
<term>Nonsteroidal drugs</term>
<term>Okada</term>
<term>Oncol</term>
<term>Peptide</term>
<term>Pilot study</term>
<term>Pivotal role</term>
<term>Polymorphism</term>
<term>Primary brain tumors</term>
<term>Prognostic factors</term>
<term>Promoter</term>
<term>Radiation therapy</term>
<term>Randomized trial</term>
<term>Receptor</term>
<term>Relative luciferase</term>
<term>Risk factors</term>
<term>Schwartzbaum</term>
<term>Snp</term>
<term>Stemline therapeutics</term>
<term>Suppressor cells</term>
<term>System tumors</term>
<term>Translational</term>
<term>Translational research</term>
<term>Translational research okada</term>
<term>Tumor gene product</term>
<term>Tumor growth</term>
<term>Vaccine</term>
<term>York academy</term>
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<term>Adult glioma</term>
<term>Allergy</term>
<term>Antiglioma immunosurveillance</term>
<term>Biological mechanisms</term>
<term>Biomarkers prev</term>
<term>Bone marrow</term>
<term>Brain tumors</term>
<term>Cancer epidemiol</term>
<term>Cancer immunol</term>
<term>Celecoxib</term>
<term>Cell response</term>
<term>Cerebral glioma</term>
<term>Clin</term>
<term>Dendritic cells</term>
<term>Epidemiologic studies</term>
<term>European organization</term>
<term>Glioblastoma</term>
<term>Glioblastoma multiforme</term>
<term>Glioblastoma risk</term>
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<term>Glioma development</term>
<term>Glioma model</term>
<term>Glioma patients</term>
<term>Glioma vaccines</term>
<term>Hideho okada</term>
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<term>Ifna8 promoter</term>
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<term>Immunologic factors</term>
<term>Immunological responses</term>
<term>International study</term>
<term>Intracranial gliomas</term>
<term>Lggs</term>
<term>Malignant glioma</term>
<term>Median survival</term>
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<term>Ndings</term>
<term>Neuro oncol</term>
<term>Nonsteroidal drugs</term>
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<term>Peptide</term>
<term>Pilot study</term>
<term>Pivotal role</term>
<term>Polymorphism</term>
<term>Primary brain tumors</term>
<term>Prognostic factors</term>
<term>Promoter</term>
<term>Radiation therapy</term>
<term>Randomized trial</term>
<term>Receptor</term>
<term>Relative luciferase</term>
<term>Risk factors</term>
<term>Schwartzbaum</term>
<term>Snp</term>
<term>Stemline therapeutics</term>
<term>Suppressor cells</term>
<term>System tumors</term>
<term>Translational</term>
<term>Translational research</term>
<term>Translational research okada</term>
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<term>Tumor growth</term>
<term>Vaccine</term>
<term>York academy</term>
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<front><div type="abstract">We recently identified a pivotal role for the host type I interferon (IFN) pathway in immunosurveillance against de novo mouse glioma development, especially through the regulation of immature myeloid cells (IMCs) in the glioma microenvironment. The present paper summarizes our published work in a number of areas. We have identified single‐nucleotide polymorphisms (SNPs) in human IFN genes that dictate altered prognosis of patients with glioma. One of these SNPs (rs12553612) is located in the promoter of IFNA8 and influences its activity. Conversely, recent epidemiologic data show that chronic use of nonsteroidal anti‐inflammatory drugs lowers the risk of glioma. We translated these findings back to our de novo glioma model and found that cyclooxygenase‐2 inhibition enhances antiglioma immunosurveillance by reducing glioma‐associated IMCs. Taken together, these findings suggest that alterations in myeloid cell function condition the brain for glioma development. Finally, in preliminary work, we have begun applying novel immunotherapeutic approaches to patients with low‐grade glioma with the aim of preventing malignant transformation. Future research will hopefully better integrate epidemiological, immunobiological, and translational techniques to develop novel, preventive approaches for malignant gliomas.</div>
</front>
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Integration of epidemiology, immunobiology, and translational research for brain tumors

Integration of epidemiology, immunobiology, and translational research for brain tumors

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri